GENT-40. DOT1L EPIGENETICALLY REGULATES AN EMT-LIKE PROCESS IN GBM BTICs
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چکیده
منابع مشابه
Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma
Epithelial-Mesenchymal Transition (EMT) is a critical step in the progression of cancer. Malignant melanoma, a cancer developed from pigmented melanocytes, metastasizes through an EMT-like process. Ten-eleven translocation (TET) enzymes, catalyzing the conversion of 5-methylcytosine (5mC) to 5-hydroxylmethylcytosine (5-hmC), are down regulated in melanoma. However, their roles in the progressio...
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Agents are of interest mainly when confronted with complex tasks. We propose a methodology for the automated design of such agents (in the framework of Markov Decision Processes) in the case where the global task can be decomposed into simpler -possibly concurrentsub-tasks. This is accomplished by automatically combining basic behaviors using Reinforcement Learning methods. The main idea is to ...
متن کاملDOT1L regulates dystrophin expression and is critical for cardiac function.
Histone methylation plays an important role in regulating gene expression. One such methylation occurs at Lys 79 of histone H3 (H3K79) and is catalyzed by the yeast DOT1 (disruptor of telomeric silencing) and its mammalian homolog, DOT1L. Previous studies have demonstrated that germline disruption of Dot1L in mice resulted in embryonic lethality. Here we report that cardiac-specific knockout of...
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DOT1L has emerged as an anticancer target for MLL-associated leukaemias; however, its functional role in solid tumours is largely unknown. Here we identify that DOT1L cooperates with c-Myc and p300 acetyltransferase to epigenetically activate epithelial-mesenchymal transition (EMT) regulators in breast cancer progression. DOT1L recognizes SNAIL, ZEB1 and ZEB2 promoters via interacting with the ...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2016
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/now212.346